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Risks for autism and depression are higher if one’s mother was in hospital with an infection during pregnancy.

Risks for autism and depression are higher if one’s mother was in hospital with an infection during pregnancy. This is shown by a major Swedish observational study of nearly 1.8 million children.

The results indicate that safeguarding against and preventing infection during pregnancy as far as possible by, for instance, following flu vaccination recommendations, may be called for,” says Verena Sengpiel, Associate Professor of Obstetrics and Gynecology at Sahlgrenska Academy, University of Gothenburg, and last author of the study, published in the journal JAMA Psychiatry.

Maternal infection with certain infectious agents, such as cytomegalovirus (CMV) or the herpes virus, are already known to be capable of harming fetal brain development and boosting the risk of certain psychiatric disorders.

The findings of the current study, however, also show that infection in general during pregnancy, too — including when the actual infectious agent does not reach the fetal brain — is related to elevated risk of the child developing autism or depression later in life.

The study is based on data on all children, totaling almost 1.8 million, born in Sweden during the years 1973–2014. The particulars from the Swedish Medical Birth Register were linked to the national inpatient register, which records whether the mother was treated in hospital with an infection diagnosis during the pregnancy concerned. Using the inpatient register, the researchers also monitored these children’s mental health until 2014, when the oldest were aged 41

Considering how much science knows about the gut-brain axis, this study might be pointing indirectly to antibiotics. Antibiotics are used to treat infections and they’re known to kill off gut bacteria, hence why it’s recommended to consume yogurt with live cultures, to help offset the massacre.

Both autism and depression studies have pointed to different gut biomes. We also know that breast feeding, and vaginal births transfer microbiota from mother to child so if mothers have decreased microbiota diversity because of taking antibiotics during pregnancy, it would be logical that their babies would experience similar.

One I know in study that if the mother has German measles while pregnant, there is a risk of the baby being born deaf. Happened in my family. I think part of the issue is the infection causes a very high fever which damages the baby as it’s developing.

A similar study suggests it might be the fever the mother develops because of the infection, not the infection or medications given for treatment. The only constant was that every woman that was hospitalized with infection suffered a fever. (Different types of infections, different microbes, different antibiotics, different antipyretics, etc.)

So Different types of infections require different kinds of antibiotics. For example, upper respiratory infections generally use zpacks, urinary tract infections usually use Cipro, ear infections usually get amoxicillin, Etc. People with viral infections don’t receive antibiotics generally, but they still run fevers like people with bacterial infections.

Women in the studies all had different types of infections so they received different types of antibiotics and no antibiotics depending on their type of infection. They also use different antipyretics (fever reducers).

This has been known for quite a while:

inflammatory disease and conditions during pregnancy — flu, colds, allergies — can all increase chances of autism.

In theory, vaccines could as well, but the odds of having a mild enough allergic reaction to a vaccine that the fetus could survive, while still having one severe enough to contribute significantly to the odds of a child becoming autistic are close to zero, while the odds of having a disease from NOT getting vaccinated that can contribute to the odds of a child becoming autistic, are many orders of magnitude higher.

So much higher that the vaccination-related autism is lost in the noise, even when studying tens or hundreds of thousands (or millions) of cases.

This means an association is found. It does not say the infection is causing it, it does not say staying at the hospital is causing it. It may be as daft as “lying in bed all day” is increasing the chance to autism. But this can be a first step in finding factors that are contributing (which is not the same as causing) to autism.

This has been known for quite a while:

inflammatory disease and conditions during pregnancy — flu, colds, allergies — can all increase chances of autism.

In theory, vaccines could as well, but the odds of having a mild enough allergic reaction to a vaccine that the fetus could survive, while still having one severe enough to contribute significantly to the odds of a child becoming autistic are close to zero, while the odds of having a disease from NOT getting vaccinated that can contribute to the odds of a child becoming autistic, are many orders of magnitude higher.

So much higher that the vaccination-related autism is lost in the noise, even when studying tens or hundreds of thousands (or millions) of cases.

The infection thing reminds me of an episode of The Nature of Things (reputable Canadian science show) . They looked at the possible connection between the gut biome and autism. It was partially about the NA diet and saw a common thread of children being given repeated antibiotics very young, usually for possible ear infections. This changed their gut biome for life. We now know the gut and brain communicate. We also overprescribe antibiotics like they are harmless candy. (yes they are life saving drugs, but over used.) As we discover more about this connection, other brain issues are being studied in relation to gut biome.

What I’m wondering is why this connection hasn’t been researched more. The possibility that it wasn’t the infection, but the antibiotics that a mother took for the infection, that caused increased autism.

A major Swedish observational study of nearly 1.8 million children. Click below

https://www.gu.se/english/about_the_university/news-calendar/News_detail//child-s-elevated-mental-ill-health-risk-if-mother-treated-for-infection-during-pregnancy.cid1619697

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